With a focused history and physical exam, an accurate diagnosis is possible in approximately 85% of patients. Differential diagnosis is different for noncholestatic and cholestatic neonatal jaundice. Differential diagnosis of obstructive jaundice springerlink. Unconjugated bilirubin and glucuronic acid combine to make conjugated bilirubin. Total serum bilirubin peaks at age 35 d later in asian infants. Anomalous findings in differential diagnosis of jaundice by. This activity is intended for pediatricians, gastroenterologists, and primary care physicians. Careful patient history and physical examination are essential in the diagnostic process. Laboratory diagnosis of jaundice linkedin slideshare. Depending on the clinical situation, jaundice and cholestasis may coexist or each. If you continue browsing the site, you agree to the use of cookies on this website. Due to substances in milk that inhibits glucuronyl transferase.
Common and important causes of jaundice for doctors and medical students this page is currently being written and will be available soon. Feb 22, 2014 differential diagnosis of icterusjaundice slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Differential diagnosis of icterusjaundice slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Differential diagnosis for jaundice oxford medical education. Large veins on the flanks and back indicate blockage of the inferior vena cava that is caused by webs or malignancy. For instance, weil syndrome, an infection caused by leptospira, a spirochete, may present with jaundice, myalgias, fevers, myocarditis, and rash. By combining meticulous scanning with a thorough knowledge of the myriad of causes of. Combine this with the fact that some patients may underplay their. This topic will provide an overview of the diagnostic approach to adults with jaundice or asymptomatic hyperbilirubinemia. Differential dx strategies university of massachusetts. History taking and physical examination for the patient with liver disease. This is a procedure combining endoscopy and xray imaging. Meinertlimitations and merits of a single serum sample analysis in the differential diagnosis of jaundice. She was a 39 week infant born by spontaneous vaginal delivery without complications who was discharged on day 2 of life with a transcutaneous bilirubin of 10.
Causes, symptoms, and treatments medical news today. A traveler with jaundice and fever medscape dec 02, 2011. Combine blood testing to reduce number of venepunctures to baby. Mean peak total serum bilirubin is 6 mgdl higher in asian infants. The scintigraphy gives correct diagnosis in 50% of the patients with hepatitis and jaundice, in 78% of the patients with cirrhosis and jaundice and in 87. Jaundice is yellowish discoloration of the skin, conjunctiva, and mucous membranes caused by hyperbilirubinemia. What is the differential diagnosis of neonatal unconjugated. The spectrum of diseases causing jaundice in older children and adolescents differs from that in the neonate and young infant. The causes of jaundice in the neonate and older infant are not the same as the causes of jaundice in the older child or adolescent figs. Usually, the concentration of bilirubin in the blood must exceed 23 mgdl for the coloration to be easily visible. Obstructive jaundice caused by biliary tuberculosis.
A comparison of these tests in acute and chronic hepatitis and in cholostatic. Differential diagnosis of jaundice parameter prehepatic. Jaundice may not be clinically evident until serum levels 3 mgdl. If your hospital, university, trust or other institution provides access to bmj best practice through services such as openathens or shibboleth, log in via this button. For the differential diagnosis for jaundice and ruq pain, click here. Painless obstructive jaundice is a hallmark of pancreatic cancer, yet several clinical and diagnostic features must be kept in mind. The differential diagnosis of jaundice sciencedirect. Full text full text is available as a scanned copy of the original print version. Aug 30, 2011 the differential diagnosis in older children and adolescents however, is very different from infants and neonates and thus will be explored here. Differential diagnosis of jaundice parameter prehepatic hepatocellular obstructive basic mechanism of raised bilirubin hemolysis leading to excess production deficient uptake, conjugation, or excretion by hepatocytes deficient excretion due to obstruction of biliary tract type of serum bilirubin increased mainly unconjugated unconjugated. The differential diagnosis of intra and extrahepatic. Blood samples may also be used to diagnose various conditions causing jaundice, such as hepatitis. Jaundice icterus is the result of accumulation of bilirubin in the bloodstream and subsequent deposition in the skin, sclera, and mucous membranes.
Differential diagnosis for obstructive jaundice oxford. Normally, serum bilirubin should never exceed 1 to 1. Jaundice is common in the neonatal period, affecting 5060% of newborns. Common and important causes of obstructive jaundice for doctors and medical students this page is currently being written and will be available soon. Neonatal jaundice background the term jaundice comes from the root jaune, the french word for yellow. What are the key indicators of lifethreatening causes of jaundice. Patients with obstructive jaundice often have claycolored stools. A 45 yearold male presents with progressive jaundice over 1 month, he denies abdominal pain. The condition may be selflimiting physiological neonatal jaundice or pathological with toxic levels of bilirubin. Jaundice consisting of either direct or indirect bilirubin, that is present at birth or appears with in the first 24 hours of life causes. Differential diagnosis jaundice can be caused by a malfunction in any of the three phases of bilirubin production tables 1 and 2. Aknowledge of the natural history of bili rubinis essential fortheclear differentiation ofthe different types ofjaundice.
This cks topic covers the recognition, differential diagnosis, and assessment of adults with jaundice presenting in primary care. Jaundice in adults can be an indicator of significant underlying disease. In our department we follow the flowchart showed in fig. Cytokines in human colostrum and neonatal jaundice. Postoperative jaundice is defined as the elevation of bilirubin that occurs after the completion of surgery and has many possible causes, associated laboratory findings, and implications. The causes of jaundice and asymptomatic hyperbilirubinemia, detailed discussions of the specific testing used, and the evaluation of patients with other liver test abnormalities are discussed elsewhere. Recommended tests will relate to your overall symptoms. A diagnosis for jaundice in adults will be determined through tests. Combining clinical risk factors with serum bilirubin levels to predict hyperbilirubinemia in newborns.
Evaluation of jaundice differential diagnosis of symptoms. Pancreatitisacuteedema of the head of the pancreas and obstruction of the common bile. The computer tomography reveals the obstructive jaundice in 94. A patient presenting with jaundice is a diagnostic challenge and the causes include a broad spectrum of diseases from very benign conditions to the most malignant. Certain strategies work better for different symptoms. The neonatal jaundice article has the common and less common differential diagnoses of neonatal jaundice. Evaluating jaundice laboratory tests direct conjugated and indirect unconjugated bilirubin alkaline phosphatase transaminases amylase cbc. Clinical and regulatory protocol for the treatment of. The differential diagnosis between intra and extrahepatic causes of jaundice was studied. Evaluating jaundice radiologic evaluation confirmation of clinically suspected biliary obstruction by demonstrating intrahepatic andor extrahepatic duct dilation identification of site and cause of the obstruction selection of the appropriate treatment modality for managing the jaundice. Jaundice is a yellow discoloration of body tissues due to an excess of bilirubin, a pigment produced during the metabolism of heme. An analysis of tests widely used in the differential diagnosis of jaundice willlall e. An analysis of tests widely used in the differential.
The differential diagnosis of neonatal hyperbilirubinemia is broad. Jaundice and asymptomatic hyperbilirubinemia are common clinical problems that can be caused by a variety of disorders, including bilirubin overproduction, impaired bilirubin conjugation, biliary obstruction, and hepatic inflammation. Strategies for generating differential diagnoses a number of different strategies can be used to generate a differential diagnosis. If bilirubin levels in babies are very high for too long. Jaundice usually occurs because of an underlying condition with the liver that. Medications are another common causes of acute liver injury. Original article from the new england journal of medicine the differential diagnosis of jaundice. It is in these cases that a diagnosis is often made by clinical experience and keen observation together with laboratory evidence. Jaundice, also known as icterus, is a yellowish or greenish pigmentation of the skin and whites of the eyes due to high bilirubin levels. An initial approach to the workup of any liver disease is to determine the acuteness of symptoms. Presence of extrahepatic diseases has to be recorded.
Started in 1995, this collection now contains 6769 interlinked topic pages divided into a tree of 31 specialty books and 732 chapters. Telega, in nelson pediatric symptombased diagnosis, 2018. Jaundice occurs by several mechanisms including hemolysis of transfused blood, reabsorptionof a hematoma, hematoperitoneum, sepsis, hypotension, and biliarytract injury. Jaundice is a condition that causes skin and the whites of the eyes to turn yellow. Although the presence of jaundice suggests pathology, it is nonspecific. Viral hepatitis is the one of the most common causes of acute onset of jaundice. Pdf a 21yearold student with fever and profound jaundice. A prospective study of 33 patients with cholestatic jaundice was performed with combined use of endoscopic retrograde cholangiopancreatography ercp, percutaneous transhepatic cholangiography ptc, ultrasonography, and liver biopsy. Breast milk jaundice correlates with high levels of epidermal. At those times adding a different strategy often reveals more conditions. Illdefined fullness in the pancreatic head consistent with pancreatic adenocarcinoma vs. Although jaundice is present in most newborns and is usually benign, it is imperative to carefully monitor newborns. Infections with bacteria and parasites may cause jaundice.
Intrahepatic causes are due to parenchymal liver disease with inability to either. A sound knowledge of the differential diagnosis of unconjugated and. It may start as early as 3rd day and reaches peak by 3rd week of life. Since it is known that an obstructive jaundice which persists for six weeks will be complicated by liver cell degeneration, surgery may finally be necessary in order to determine the cause of the jaundice. Jaundice in the newborns jaundice is the most common morbidity in the first week of life, occurring in 60% of term and 80% of preterm newborn.
Differential diagnosis differentialdiagnosis oficterus. She had been breastfeeding well, with several stools and many voids. The rationale of such tests in the differential diagnosis of jaundice rests on the assumptions that 1 the measured ab normality specifically reflects polygonal cell damage and 2 evidence of polygonal cell damage is specific for medical jaundice. Combined approach to the differential diagnosis of. Differential diagnosis ascites refers to the pathologic accumulation of fluid within the peritoneal cavity. Breast milk jaundice correlates with high levels of epidermal growth factor. It is caused by elevated serum bilirubin levels in the unconjugated or conjugated form. The diagnosis of zieve syndrome was confirmed based on hemolysis and cholestatic jaundice secondary to alcoholic liver disease and heavy drinking. Ultrasound ct abdomenpelvis markedly dilated intrahepatic biliary ducts, common bile duct and pancreatic duct. A practical approach to neonatal jaundice american family. At the 20 noviembre issste hospital in mexico city, between january 1977 and may 1984, data were.
Differential diagnosis indirect unconjugated hyperbilirubinemia. Get a printable copy pdf file of the complete article 686k, or click on a page image below to browse page by page. Jaundice is the most common cause of readmission after discharge from birth hospitalization. The total amount of bilirubin in the body will be determined through a blood sample. Evaluating jaundice radiologic evaluation confirmation of clinically suspected biliary. The differential diagnosis for jaundice can be described by all of these etiologies. Levels above 2 mgdl result in detectable jaundice, first in the sclerae, next under the tongue and along the tympanic membranes, and finally in the skin. Summary jaundice is a clinical sign describing yellow pigmentation of the skin, sclera, and mucous membranes due to raised plasma bilirubin. The excess bilirubin may exist in the unconjugated indirect or the conjugated direct form. Neonatal jaundice is a common type of jaundice that happens to newborn babies. To be updated when it is complete please like us on facebook, follow us on twitter or subscribe on youtube using the follow us buttons. Pancreatitisacuteedema of the head of the pancreas and obstruction of the common bile duct can cause jaundice.
Patient presentation a 3dayold female came to clinic with jaundice. Certain conditions may cause nonphysiologic jaundice. Table 1, lists guidelines related to jaundice that are helpful for the practicing emergency. Approach to the patient with ascites differential diagnosis. Neonatal jaundice physiologic jaundice nonpathologic unconjugated hyperbilirubinemia. Jaundice in babies occurs in over half in the first week following birth and does not pose a serious threat in most.
The treatment of jaundice in adults and elderly subjects is amongst the themes selected for elaborating the crps since jaundice is a medical sign frequently seen in four clinical scenarios involving distinctive diagnostic and therapeutic interventions which can be performed in different health care settings. The first critical step is to differentiate intra and extrahepatic cholestasis. Neonatal jaundice differential diagnoses emedicine. Its pathogenesis and differential diagnosis jama network. Bilirubin is a break down product of haemoglobin, manufactured by the reticuloendothelial system mainly in the spleen and bonemarrow but also in any other organs or tissues of the body where. Important to make correct diagnosis because some disorders can progress rapidly, but can be treated. See classification and causes of jaundice or asymptomatic hyperbilirubinemia. Us approach to jaundice in infants and children radiographics. It can, but not always, be associated with icterus.
Kumral a, ozkan h, duman n, yesilirmak dc, islekel h, ozalp y. A higher rate of success with ptc in 25 cases of extrahepatic cholestasis was offset by the better score of ercp in 8 cases of intrahepatic. After generating a differential, you may decide that you would like to expand upon it. The purpose of the present study is to analyze further the value of the con ventional and most widely used tests in the differential diagnosis of jaundice. Bile acids combine with glycine or taurine to form complex salts or acids. This patient initially presented with painless jaundice and computed tomography ct revealed a mass in the head of the pancreas. The goals of this activity are to improve clinicians ability to recognize uncommon causes of pediatric cholestatic jaundice and to order the proper tests to identify treatable disorders. Jul 29, 2016 differential diagnosis of jaundice parameter prehepatic hepatocellular obstructive basic mechanism of raised bilirubin hemolysis leading to excess production deficient uptake, conjugation, or excretion by hepatocytes deficient excretion due to obstruction of biliary tract type of serum bilirubin increased mainly unconjugated unconjugated. Apr 21, 2008 patient presentation a 3dayold female came to clinic with jaundice. Erythroblastosis fetalis high direct bilirubin in infants who were given intrauterine transfusions. Ok, whereas i think the section in criglernajjar syndrome doesnt have much to add.
The differential diagnosis of jaundice, or hyperbilirubinemia, is often organized pathophysiologically. More common causes are listed first, followed by less common causes. Download the pdf to view the article, as well as its associated figures and tables. Jul 30, 2018 neonatal jaundice is a common type of jaundice that happens to newborn babies. If you have a best practice personal account, your own subscription or have registered for a free trial, log in here. In any patient with jaundice, the total serum bilirubin should be fractionated, as the. The differential diagnosis of cholestatic disorders can be wide table 1.
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